The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice.

ABSTRACT: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP) neuropeptide family and plays a role in the regulation of several releasing hormones and tropic hormones. The hypothalamic-pituitary-gonadal (HPG) axis governs the synthesis and the release of sex hormones and the gametogenesis in all mammals. While the effects of PACAP on fertility is well-documented in females, much less data are available in males. The aim of our study was to examine potential structural and expressional changes in the hypothalamus that might underlie the fertility deficits observed in male PACAP knockout (KO) mice. To this end, we performed immunofluorescent, immunohistochemical and RNAscope in situ hybridization stainings to detect the protein and/o

SUBMITTER: Faludi P 

PROVIDER: S-EPMC12673620 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature