Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage.

ABSTRACT:

Background

Time-restricted feeding (TRF), a type of intermittent fasting, has been shown to improve blood pressure; however, there is limited data on its effects in salt-sensitive (SS) hypertension. We hypothesized that TRF intervention would attenuate the progression of hypertension and renal damage in Dahl SS rats on a high-salt diet.

Methods

Chronic 24-hour femoral mean arterial pressure (MAP) was recorded during 1 week of ad libitum low-salt or high-salt feeding, followed by 1 week of ad libitum feeding or TRF (16 hours fasting: 8 hours ad libitum) of the same diet. Cosinor analysis was performed on MAP traces. Comprehensive metabolic phenotyping was performed during the second week of the study. Sodium excretion and creatinine clearance were assessed in 4-hour windows o

SUBMITTER: Yunker L 

PROVIDER: S-EPMC12673638 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature