Initial Circulating CD138 Predicts End-Stage Kidney Disease in Patients with Microscopic Polyangiitis.

ABSTRACT:

Purpose

CD138 is a cell surface proteoglycan involved in plasma cell survival and cell adhesion, and can be detected in serum via ectodomain shedding. This study aimed to investigate the clinical utility of circulating CD138 at diagnosis in predicting future progression to end-stage kidney disease (ESKD) in patients with microscopic polyangiitis (MPA).

Materials and methods

Sixty-five patients newly diagnosed with MPA were included. Antineutrophil cytoplasmic antibody-associated vasculitis-specific indices and clinical and laboratory data were collected. Circulating CD138 levels were measured from stored sera at the time of diagnosis and a cut-off value for predicting ESKD progression was determined using receiver operating characteristic curve analysis.

Results

The m

SUBMITTER: Pyo JY 

PROVIDER: S-EPMC12673651 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature