Sleep Traits and Risk of Epilepsy: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study.

ABSTRACT:

Purpose

Sleep traits are suggested as risk factors for epilepsy, yet the extent of their shared biological basis and the causal direction between these traits are not well understood. Our goal was to assess the associations and establish causal relationships between sleep traits and epilepsy through Mendelian randomization (MR) analyses.

Materials and methods

Univariate and multivariate bidirectional MR analyses were used to assess the causal association between sleep traits and epilepsy. In this study, exposure factors of seven sleep traits and outcome variables related to epilepsy were obtained from the published Genome-Wide Association Study (GWAS). The major analysis utilized for MR was inverse-variance weighted.

Results

Univariable MR analysis indicated that both

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12673657 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature