Risk factors and early prediction of pancreatic cancer among patients with diabetes mellitus: a systematic review and meta-analysis.

ABSTRACT:

Aim

Diabetes mellitus (DM) increases the risk of pancreatic cancer (PC). This study evaluates risk factors for PC in DM patients and the predictive accuracy of machine learning (ML) models to provide research-backed data for the development and update of intelligent prediction tools.

Methods

PubMed, Cochrane, Embase, and Web of Science were systematically retrieved, up to December 1, 2024. The quality of the original studies was assessed through the Newcastle-Ottawa Scale (NOS). A meta-analysis was conducted on the c-index that reflects the comprehensive accuracy of the prediction models.

Results

18 studies were included. The rough annual incidence of PC among DM was estimated at 0.4% (95% CI: 0.1% - 0.9%), and the incidence rates of PC for new-onset DM and pre-existi

SUBMITTER: Cong H 

PROVIDER: S-EPMC12673663 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature