Comprehensive 4D Parallel Transmission Spatial-Spectral Pulse Design for Slab-Selective Uniform Water-Selective Excitation: Demonstration in the Human Brain at 7 Tesla.

ABSTRACT:

Purpose

To propose a new parallel transmission (pTx) spatial-spectral (SPSP) pulse design for achieving slab-selective uniform water-selective excitation without unwanted out-of-slab fat excitation when using bipolar slab-selective gradients to maintain a sharp slab profile.

Methods

Our new pTx SPSP pulses were designed by formulating the design problem comprehensively in the 4D space (1D spectral and 3D spatial domains) and by incorporating a SPINS-like 2D excitation k-space trajectory for within-slab flip-angle homogenization. Our new design was validated at 7 T using simulation, phantom and human experiments with the commercial Nova eight-channel transmit RF head coil. Its utility was demonstrated by comparing to traditional multi-spoke pTx SPSP pulses.

Results

In

SUBMITTER: Shao X 

PROVIDER: S-EPMC12673673 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature