Development and validation of the Hypotensive Exposure Duration Index for mortality risk prediction in critically ill patients.

ABSTRACT:

Background

Blood pressure management is crucial in critical care, but relationships between pressure patterns and outcomes remain incompletely understood. We analyzed minute-by-minute blood pressure data to develop and validate a novel index quantifying hypotensive exposure burden.

Methods

In this retrospective study using the Salzburg Intensive Care Database, 11,059 ICU admissions with continuous invasive arterial monitoring were analyzed. Heatmaps were constructed from high-resolution hemodynamic data to visualize relationships between blood pressure thresholds (52-120 mmHg), exposure durations (5 min-5 h), and mortality. The Hypotensive Exposure Duration Index (HEDI) was developed to quantify cumulative hypotensive burden by integrating exposure across multiple MAP thresh

SUBMITTER: Ding XY 

PROVIDER: S-EPMC12673709 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature