Cell surface display of VP1 of foot-and-mouth disease virus on Saccharomyces cerevisiae.

ABSTRACT:

Background

Foot-and-mouth disease (FMD) is a highly infectious disease that mainly affects cloven-hoofed animals. The rapid spread of this disease hinders the success of control measures. This necessitates the urgent development of a vaccine to ensure the safe rearing of affected animals. However, traditional vaccines have some drawbacks including partial protection against persistent infection and a lack of cross-protection against different strains.

Results

We developed an oral vaccine that targets VP1, the major immunogenic protein of the causative FMD virus (FMDV). We expressed this protein using the surface display method and subsequently analyzed its immune efficacy. Western blot analysis and confocal imaging confirmed that our constructs effectively expressed VP1 on t

SUBMITTER: Le NMT 

PROVIDER: S-EPMC12673714 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature