Robot-assisted total hip arthroplasty following gene therapy for hemophilia a arthropathy: a case report.

ABSTRACT:

Background

Hemophilia A (HA) arthropathy poses a significant clinical challenge, particularly in achieving perioperative hemostasis and surgical precision. Accounting for the majority of hemophilia cases, HA frequently leads to severe secondary joint damage. Although gene therapy holds promise, its clinical application in HA remains limited by challenges to durable efficacy. Crucially, the transient efficacy and unpredictable pharmacokinetics of gene therapy have not been evaluated in major orthopedic surgeries with a high potential for bleeding, such as total hip arthroplasty (THA).

Case presentation

To our knowledge, this is the first documented case of robot-assisted (RA)-THA performed after gene therapy for severe HA-associated hip arthropathy, including a detailed surgi

SUBMITTER: Wu C 

PROVIDER: S-EPMC12673715 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature