The Kv10.1 potassium channel, driver of hypoxia-induced EMT and breast cancer cell aggressiveness.

ABSTRACT:

Background

Kv10.1 potassium channel has been shown to be involved in breast cancer luminal cell proliferation and survival as well as migration in basal cell model in normoxia. Moreover, it is clearly established that solid tumors present a hypoxic center. Currently, few information is available about the involvement of the Kv10.1 channel in hypoxic context in breast cancer progression.

Methods

We explored the role of Kv10.1 in the hypoxia-induced aggressiveness promotion of different breast cancer cell models: luminal A (MCF-7 cells), HER2-overexpressing (SKBr3 cells) and basal subtype (MDA-MB-231 cells) by using complementary approaches of cell biology assay, western blot and qPCR.

Results

Our results show that Kv10.1 expression and function are related to hypoxia a

SUBMITTER: Laine M 

PROVIDER: S-EPMC12673720 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature