Extracellular vesicle-derived miR21 of non-tumoral origin as early diagnostic marker of glioma.

ABSTRACT:

Background

Extracellular vesicles (EVs) are key elements in intercellular communication and are released into body fluids by all cells in physiological and pathological conditions. In brain tumors, EVs facilitate the bidirectional communication between neoplastic cells and the tumor microenvironment, promoting tumor progression and immune evasion. Among the various components of the EVs, microRNAs (miRs) act as potent regulators of gene expression. In particular, miR21 has gained attention as both a promising diagnostic biomarker and a key contributor to GBM progression.

Methods

This study employed content analysis of miRs in EVs isolated from the brain, plasma, and urine of glioma-bearing mice.

Results

Seven days after glioma cell injection, miR21 was the most highly

SUBMITTER: De Luca M 

PROVIDER: S-EPMC12673766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature