Efficacy of metastasis-directed therapy in de novo metastatic nasopharyngeal carcinoma patients receiving chemo-immunotherapy and local regional radiotherapy: a multicenter retrospective study.

ABSTRACT:

Objective

To develop a prognostic model that predicts outcomes and identifies ideal candidates for metastasis-directed therapy (MDT) in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) after chemo-immunotherapy and locoregional radiotherapy (LRRT).

Methods

Dm NPC patients receiving chemo-immunotherapy followed by LRRT across four centers were enrolled. Propensity score matching (PSM) analysis was conducted to compare progression-free survival (PFS) between patients who received MDT and those who did not. A predictive nomogram was developed to stratify patients and identify candidates for MDT.

Results

A total of 364 patients were included in this study. Of these, 94 patients received MDT, while 270 patients did not. PSM analysis revealed that MDT was a

SUBMITTER: He SQ 

PROVIDER: S-EPMC12673791 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature