Multi-omics integrated analysis identifies causal risk factors and therapeutic targets for diabetic retinopathy.

ABSTRACT:

Background

Diabetic retinopathy (DR) is the main cause of blindness worldwide, and its prevalence rate is constantly rising. More in-depth exploration of its risk factors and pathogenic mechanisms is needed.

Methods

This study systematically identified potential therapeutic targets for DR by evaluating causal effects of 16,989 genes and 2,923 proteins on DR/subtypes via two-sample Mendelian randomization (MR), validated with colocalization/Summary-data-based Mendelian randomization (SMR). National Health and Nutrition Examination Survey (NHANES) 1999-2010 cross-sectional data (weighted logistic/Restricted cubic spline (RCS)) pinpointed key risk factors; MR explored their links to DR subtypes. Bioinformatics (bulk and single-cell transcriptomics) analyzed molecular mechanisms

SUBMITTER: Xu J 

PROVIDER: S-EPMC12673795 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature