Extracts from Plectranthus asirensis and Premna resinosa inhibit Helicobacter pylori-induced epithelial cell damage, DNA double-strand breaks and inflammation.

ABSTRACT:

Background

Helicobacter pylori infection is a major global health issue associated with chronic gastritis, peptic ulcers, and gastric cancer. Due to the increasing resistance of H. pylori to conventional antibiotics, there is growing interest in researching alternative therapeutic agents, particularly those from medicinal plants.

Methods

Preparation and purification of extracts from two plant species, Plectranthus asirensis and Premna resinosa, were performed by cold maceration. The anti-microbial activity of two extracts was then evaluated against H. pylori to determine the minimum inhibitory concentration (MIC). The activity of the extracts was further analyzed by electron microscopy, bacterial cell lysis and Western blotting. The effects on AGS gastric epithelial cells up

SUBMITTER: Noman O 

PROVIDER: S-EPMC12673798 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature