Bleeding Outcomes of Ticagrelor Versus Clopidogrel in Acute Coronary Syndrome Patients: A Multiethnic Database Study.

ABSTRACT:

Background

Compared with Caucasians, East Asians with acute coronary syndrome (ACS) respond differently to P2Y₁₂ inhibitors.

Objectives

The purpose of this study was to compare bleeding outcomes between ticagrelor and clopidogrel, and identify bleeding predictors in a multiethnic South-East Asian ACS cohort.

Methods

We conducted a retrospective, propensity-matched, nationwide database cohort study of ACS patients who underwent coronary revascularization in Singapore, and compared 1-year bleeding outcomes of ticagrelor and clopidogrel. Independent bleeding predictors were investigated using multivariate logistic regression analysis.

Results

Between January 2013 and December 2017, 14,812 ACS patients (8,502 [57%] clopidogrel and 6,310 [43%] ticagrelor)

SUBMITTER: Loh GL 

PROVIDER: S-EPMC12673823 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature