Sleep Patterns and Frailty: Joint Impact on Major Adverse Cardiac Events.

ABSTRACT:

Background

Sleep patterns and frailty phenotypes are becoming increasingly important metrics for assessing cardiovascular disease (CVD) risk; however, research investigating their synergistic effects on major adverse cardiac events (MACE) remains scarce.

Objectives

This study aimed to investigate how sleep patterns and frailty phenotypes jointly influence MACE.

Methods

A total of 380,105 participants from the UK Biobank were included for the analysis. Frailty phenotypes and sleep patterns were defined based on the frailty scores and sleep scores, respectively. Cox proportional hazards models were used to evaluate the associations between combinations of frailty phenotypes and sleep patterns and MACE, including nonfatal myocardial infarction, stroke, or CVD-related dea

SUBMITTER: Chen ZT 

PROVIDER: S-EPMC12673830 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature