Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences.

ABSTRACT: Interactions between biomolecules govern cellular biology. While protein/protein and protein/nucleic acid (DNA, RNA) interactions-and, to a lesser extent, RNA/RNA and RNA/DNA interactions-have been extensively described, a question remains as to whether and how non-canonical DNA structures might interact with each other. This is of particular interest for guanine (G)-rich sequences that can fold into G-quadruplex (G4) structures: Individual G4s are currently studied for their involvement in a myriad of cellular events (mostly pertaining to the control of gene expression), and, more recently, the interactions between two G4s have been scrutinized as being part of a novel gene expression regulatory mechanism involving chromatin remodeling through G4-mediated loop formation. The question that

SUBMITTER: Xia J 

PROVIDER: S-EPMC12673844 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature