Differential Impact of Pneumococcal Conjugate Vaccines on Hospitalized <i>Versus</i> Outpatient Community-Acquired Alveolar Pneumonia in Children Younger Than 5 Years Suggests Differences in Pathogenesis.

ABSTRACT:

Background

Current evidence suggests that in young children with community-acquired alveolar pneumonia (CAAP), bacterial-viral coinfections (mostly respiratory syncytial virus [RSV]-pneumococcus coinfections) are more prevalent among hospitalized children than among outpatients and that RSV-pneumococcal coinfections are more frequently associated with non-PCV13 serotypes. Based on this background, we speculated that following pneumococcal conjugate vaccine [PCV] implementation, the decline of hospitalized CAAP episodes would be lower than that of outpatient episodes.

Methods

This analysis was a part of an ongoing (since 2004) population-based, active surveillance in children < 5 years, including all CAAP visits to the pediatric emergency room in southern Israel. Community-ac

SUBMITTER: van der Beek BA 

PROVIDER: S-EPMC12673847 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature