Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection.

ABSTRACT:

Background

Zika virus (ZIKV) emergence in 2015-2016 was characterized by high attack rates and a wave of Congenital Zika Syndrome cases that affected several countries in the Americas. The sudden drop in virus transmission in the following years and the lack of a reliable correlate of protection have hampered the development of vaccines. ZIKV neutralizing antibodies (nAbs) responses to natural ZIKV infection provide insights into the potential efficacy of vaccine candidates.

Methods

In this study, we compared anti-ZIKV nAb responses generated by a ZIKV vaccine (TAK-426), to those elicited by natural ZIKV infection in participants from diverse geographic areas using the same neutralizing antibody assay.

Results

Those with a ZIKV infection (inapparent or symptomatic) ex

SUBMITTER: Galindo CM 

PROVIDER: S-EPMC12673849 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature