Exacerbation of Dahl SS Hypertension and Renal Damage by NOX2 in CD4+ T Cells.

ABSTRACT:

Background

Infiltration of T cells into the kidney of Dahl salt-sensitive (SS) rats accompanies SS hypertension and renal damage. Genetic deletion of T cells on the SS background (SS^CD247-/-) attenuates hypertension and renal damage, and adoptive transfer of T cells restores the disease phenotype in an NOX2 (NADPH oxidase 2)-dependent manner. This study aimed to identify the specific T-cell subtype involved in the amplification of Dahl SS hypertension.

Methods

Adoptive transfer of purified CD (cluster of differentiation) 4+ or CD8+ T cells isolated from SS rats or from rats with a genetic deletion of a subunit of NOX2 was performed into the SS^CD247-/-. A negative control group received PBS vehicle. After 3 weeks of a high-salt (4.0

SUBMITTER: Walton SD 

PROVIDER: S-EPMC12673866 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature