Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction.

ABSTRACT: The deoxygenative difunctionalization of carbonyls converts readily available carbonyl compounds into value-added gem-difunctionalized building blocks. We report an electrochemical carbonyl umpolung approach for the deoxygenative cyanofunctionalization of aldehydes and ketones, affording various α-functionalized nitriles. Further derivatization of these products provides a versatile and modular platform for geminal disubstitution of carbonyl oxygens.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12673927 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature