Sublethal interaction factor (SIF), a growth-based method to analyze antibiotic combinations at sub-inhibitory concentrations.

ABSTRACT: Antibiotic resistance is a global concern with significant implications for healthcare, food production, and the environment. Therapies involving antibiotic combinations are frequently employed as a strategy to overcome antibiotic resistance. When present in combination, the efficacy of antibiotics may be enhanced or weakened, and as antibiotic interactions are a priori generally unpredictable, they need to be experimentally determined. Though antibiotics are regularly present at sublethal concentrations (e.g., in patients with suboptimal dosing regimens, late after the last dosage, difficult-to-penetrate tissues, and also in the natural environment), effects of antibiotic combinations are generally studied at lethal dosages. To address this, we developed the sublethal interaction f

SUBMITTER: Sanchez-Hevia DL 

PROVIDER: S-EPMC12673930 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature