A Qualitative Exploration of Adherence to Methotrexate in Juvenile Idiopathic Arthritis.

ABSTRACT:

Objective

To identify barriers and facilitators of adherence to methotrexate (MTX) in juvenile idiopathic arthritis (JIA).

Study design

We conducted a qualitative cross-sectional study employing semistructured interviews of 20 adolescents with JIA with varying levels of MTX adherence, determined by pharmacy dispense data. We used grounded theory to identify common themes, which we organized into barriers and facilitators, subdivided into World Health Organization adherence domains.

Results

The sample had equal representation of adherent and nonadherent patients, and of those prescribed oral and injectable MTX. The most common barriers were patient- or medication-related, including anticipatory nausea, anxiety, busy schedules, side effects, and the color, taste, and od

SUBMITTER: Abel D 

PROVIDER: S-EPMC12673932 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature