Ventilatory Complexity Persists in Phox2b Mutant Mice Lacking the Retrotrapezoid Nucleus/Parafacial Respiratory Group (RTN/pFRG) and in Humans With Congenital Central Hypoventilation Syndrome.

ABSTRACT: Breathing is inherently variable due to the nonlinear dynamics of its brainstem neural control. In amphibians, a gill and a lung oscillator interact to produce breathing but the lung oscillator is necessary and sufficient to produce a mathematically complex behavior. In mammals, where the preBötzinger complex (preBötC) is considered homologous to the amphibian lung oscillator and the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) homologous to the amphibian gill oscillator, the origin of ventilatory complexity is not known. We address this question by characterizing ventilation variability in Phox2b mutant mice lacking the RTN/pFRG and human patients with Phox2b mutation-confirmed congenital central hypoventilation syndrome (CCHS). Ventilatory recordings were obtained from

SUBMITTER: Straus C 

PROVIDER: S-EPMC12673958 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature