Collagen processing is essential for germ cell identity.

ABSTRACT: The extracellular matrix (ECM) is a critical component of embryonic development, providing both structural support and a dynamic signaling environment for cell migration, adhesion, and tissue organization. Collagen, the most abundant protein in the ECM, is crosslinked by the enzyme lysyl oxidase (LOX), and that activity plays a pivotal role in creating support throughout the ECM. Dysregulated LOX activity disrupts the mechanical integrity of the ECM. Sea urchins offer a robust model for studying LOX function and ECM dynamics in embryonic development due to their rapid, transparent development and traceable cell lineages. Previous studies using the pan-monoamine oxidase/LOX inhibitor β-aminopropionitrile suggested an essential role of LOX activity in sea urchin gastrulation and maintenance

SUBMITTER: Roman S 

PROVIDER: S-EPMC12673967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature