Association between pyramidal neurone spiking in the medial prefrontal cortex and the sedative potency of volatile anaesthetics in mice.

ABSTRACT:

Background

The mechanisms underlying volatile anaesthetic-induced unconsciousness remain unclear. Glutamatergic pyramidal neurones and fast-spiking interneurones in cerebral cortex circuits play distinct roles in cortical network dynamics under volatile anaesthesia. We investigated the roles of medial prefrontal cortex (mPFC) pyramidal and fast-spiking interneurones in volatile anaesthetic-induced hypnosis.

Methods

The electrophysiological properties of pyramidal and fast-spiking parvalbumin (PV⁺) neurones were explored by in vivo multichannel recordings and in vitro patch-clamp electrophysiological recordings. Chemogenetic manipulation was used to test the role of pyramidal neurones in the mPFC in volatile anaesthetic-induced unconsciousness. Na_v1.1 kn

SUBMITTER: Leng Y 

PROVIDER: S-EPMC12674074 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature