Whole-genome resequencing reveals new mutations in candidate genes for Beichuan-white goat prolificacya.

ABSTRACT: In this study, we evaluated the copy number variation in the genomes of two groups of Beichuan-white goat populations with large differences in litter size by F_ST method, and identified 1739 genes and 485 missense mutations in the genes subject to positive selection. Through functional enrichment, ITGAV, LRP4, CDH23, TPRN, RYR2 and CELSR1 genes, involved in embryonic morphogenesis, were essential for litter size trait, which received intensive attention. In addition, some mutation sites of these genes have been proposed (ITGAV: c.38C > T; TPRN: c.133A > T, c.1192A > G, c.1250A > C; CELSR1: c.7640T > C), whose allele frequencies were significantly changed in the high fecundity goat group. Besides, we found that new mutations at the

SUBMITTER: Zhou A 

PROVIDER: S-EPMC12674176 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature