Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain.

ABSTRACT:

Background/objectives

Patients with epilepsy commonly experience patterns of seizures that change with sleep/wake behavior or diurnal rhythms. The cellular and molecular mechanisms that underlie these patterns in seizure activity are not well understood but may involve non-neuronal cells, such as astrocytes. Our previous studies show the critical importance of one specific astrocyte factor, the brain-type fatty acid binding protein Fabp7, in the regulation of time-of-day-dependent electroshock seizure threshold and neural activity-dependent gene expression in mice. Here, we examined whether Fabp7 influences differential seizure activity-dependent protein expression, by comparing Fabp7 knockout (KO) to wild-type (WT) mice under control conditions and after reaching the maxima

SUBMITTER: Berg AP 

PROVIDER: S-EPMC12674186 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature