DNA methylation-predicted protein differences between Yakutian and Central Russian populations.

ABSTRACT:

Background

Populations in subarctic regions, like Yakutia in the Russian Sakha Republic, have adapted to extreme environmental conditions, including intense cold, pronounced shifts in daylight, and variable food availability. However, the biological mechanisms underlying these adaptations remain poorly understood despite insights from genome-wide (GWAS) and epigenome-wide association studies (EWAS).

Methods

Since protein profiles may more directly reflect functional physiology, we analyzed DNA methylation data from 245 healthy Russian participants using methylation-based estimators of circulating protein levels to investigate estimated proteomic differences between residents of Yakutia and Central Russia.

Results

We identified regional variation in 25 protein surrogat

SUBMITTER: Nwanaji-Enwerem JC 

PROVIDER: S-EPMC12674273 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature