Trajectories of Areal Bone Mineral Density Significantly Differ by Patterning of Femoral Neck Area and Bone Mineral Content Across the Menopausal Transition.

ABSTRACT: Clinical use of areal bone mineral density (aBMD) to identify fracture risk assumes that aBMD reflects bone mineral content (BMC). Yet, aBMD is calculated using a ratio of BMC and bone area, thus declines in aBMD may reflect a decline in BMC, an increase in bone area, or both. This study identifies groups of individuals defined based upon patterns of change in BMC and bone area across the menopausal transition (MT). The Michigan Bone Health and Metabolism Study is a longitudinal study of women; participants aged 24-50 were recruited in 1992 and followed near annually through 2010. At each visit, a DXA of the femoral neck was assessed. This analysis is based upon data from 97 women with an observed non-surgical final menstrual period (FMP); a dual-energy X-ray absorptiometry (DXA) scan 10 y

SUBMITTER: Leis AM 

PROVIDER: S-EPMC12674337 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature