Copy number variations within fibroblast growth factor 13 gene influence growth traits and alternative splicing in cattle.

ABSTRACT: Previous researches revealed a copy number variation (CNV) region in the bovine fibroblast growth factor 13 (FGF13) gene. However, its effects remain unknown. This study detected the various copy number types in seven Chinese cattle breeds and analysed their population genetic characteristics and effects on growth traits and transcription levels. Copy number Loss was more frequent in Caoyuan Red cattle and Xianan cattle than in the other breeds. Association analysis between CNV and growth traits of Qinchuan indicated that the CNV was significantly related to chest depth, hip width and hucklebone width (P < 0.05). Additionally, the growth traits of individuals with copy number Loss were significantly inferior to those with copy number Gain or Median (P < 0.05). Besides,

SUBMITTER: Cai H 

PROVIDER: S-EPMC12674343 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature