The efficiency of rotavirus A spread to extraintestinal tissues is not determined by the levels of its replication in the gut.

ABSTRACT: Rotavirus A (RVA) spreads to multiple extraintestinal organs; however, it is not well understood what viral or host characteristics regulate the efficiency of this spread. We conducted this study to determine whether more efficient intestinal RVA replication leads to a higher rate of its extraintestinal spread. We also examined the distribution of known RVA glycan receptors in different tissues to better understand their potential role in facilitating viral dissemination to extraintestinal sites. We inoculated germ-free pigs with porcine OSU G5P[7] characterized by remarkably robust in vitro/in vivo replication, and G9P[13] which replicates to low-to-moderate titers and several other strains. Significantly higher RVA titers were observed in intestinal tissue/contents/feces of pigs infected

SUBMITTER: Raev SA 

PROVIDER: S-EPMC12674514 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature