Amino acid metabolism of the thermophilic acetogen Thermacetogenium phaeum.

ABSTRACT: Anaerobic microbial degradation of the amino acids glycine and serine either occurs through enzymes of the so-called Stickland reaction or alternatively through the glycine cleavage system (GCS). In the mesophilic anaerobe Peptoclostridium acidaminophilum, initial glycine degradation proceeds through disproportionation to methylene tetrahydrofolate (THF) and acetyl-phosphate by GCS and glycine reductase. The thermophilic acetogen Thermacetogenium phaeum is able to utilize glycine, serine or threonine as sole carbon source, although it lacks genes for glycine reductase. In contrast, T. phaeum possesses genes for the GCS as well as for serine-converting enzymes, and the corresponding enzymes were specifically overabundant in the proteome and active. Among these enzymes, serine dehydratase wa

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12674515 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature