Phosphatase PP2A promotes RTA dephosphorylation to impair KSHV lytic replication.

ABSTRACT: Kaposi's Sarcoma-associated herpesvirus (KSHV) is a human γ herpesvirus that establishes two different phases in its life cycle, the latency and lytic replication. KSHV-encoded replication and transcription activator (RTA), an immediate-early master switch protein, plays a central role in switching the viral latency to lytic replication. Extensive studies have described the mechanisms that RTA functions as a transcription factor to activate its downstream viral genes expression, initiating lytic replication. Phosphorylation of RTA has been shown to be critical for its function, but the regulatory mechanisms of phosphorylation and dephosphorylation of RTA have not been fully elucidated. In this study, we showed that RTA interacts with the scaffold protein PPP2R1A of phosphatase PP2A. We nex

SUBMITTER: Bai L 

PROVIDER: S-EPMC12674568 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature