Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome.

ABSTRACT:

Background and purpose

We aimed to explore the mechanisms and pathways of exercise-based interventions in the treatment of polycystic ovarian syndrome (PCOS).

Methods

In this literature review, studies related to exercise therapy for PCOS that were published in the past 20 years were searched, potentially effective active ingredients were screened, and gene prediction of active ingredients and diseases was conducted using the compound and GeneCards databases, respectively, to identify potential targets of exercised-related bioactive molecules in PCOS. Finally, hub genes and signaling pathways were predicted using bioinformatic methods.

Results

The review identified eight potential effective components were screened out, including irisin, 5α-reductase, kisspeptin, coca

SUBMITTER: Yang X 

PROVIDER: S-EPMC12674599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature