Mechanistic Insight into Tyrosine Oxidation at Carbon-Fiber Microelectrodes Revealed by Fast-Scan Cyclic Voltammetry.

ABSTRACT: A comprehensive understanding of tyrosine (Tyr) redox behavior will allow for improved electroanalytical monitoring and can shed light on complex biochemical processes. However, the study of Tyr at carbon electrodes is impeded by electrode fouling, which obfuscates quantitative analysis and mechanistic interpretation. In this study, fast-scan cyclic voltammetry (FSCV) was used to characterize Tyr redox properties at carbon-fiber microelectrodes. Tyr exhibited a distinct anodic peak indicative of irreversible redox chemistry that was modeled as a single-proton and single-electron transfer reaction combining surface-adsorbed and diffusing species. The adsorption properties and additional reactions were dependent on experimental conditions. Tyr accumulated on the electrode surface when negati

SUBMITTER: Todorov J 

PROVIDER: S-EPMC12674612 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature