Structural Brain Abnormalities and Neuropsychiatric Symptoms in Post-COVID Condition.

ABSTRACT:

Objectives

We aimed to cross-sectionally and longitudinally compare brain morphometry and neuropsychiatric symptoms, and evaluate their relationship, in participants with Post-Coronavirus Disease Condition (PCC) and healthy Controls.

Methods

At Baseline, 29 PCC (19 female; average age=42.4±12.2 years; 242±156 days since infection) and 25 Controls (14 female; 44.1±12.3 years) completed the NIH Toolbox Emotion, Motor and Cognition Batteries; Patient Reported Outcomes Measurement Information System (PROMIS); and structural brain MRI (thickness, areas, volumes). We compared neurobehavioral performance on the NIH Toolbox and PROMIS and structural brain morphometry for 34 cortical regions and 8 subcortical volumes, between PCC and matched Controls at Baseline (~8 months post-infec

SUBMITTER: Ryan M 

PROVIDER: S-EPMC12674627 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature