Subtype- and Layer-Specific Developmental Gradients of Postnatal GABAergic Neurons in the Rodent Barrel Cortex.

ABSTRACT:

Introduction

The developing brain exhibits rostro-caudal gradients that align with the maturation of functionally organized circuits. The barrel cortex, a spatially precise sensory structure, serves as an ideal model to examine such gradients within a confined functional domain. GABAergic interneurons, characterized by subtype-specific developmental trajectories and pivotal roles in early cortical dynamics, provide a strategic cellular entry point for this investigation.

Methods

To explore cellular and functional gradients in the developing barrel cortex, we combined transgenic mouse lines, immunohistochemical analyses with in vivo electrophysiological recordings of whisker-evoked activity during early postnatal stages. We also employed a model of ethanol exposure to assess

SUBMITTER: Kallo H 

PROVIDER: S-EPMC12674656 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature