Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.

ABSTRACT:

Introduction

Neighborhood deprivation is associated with shorter survival, cognitive impairment, and neurodegeneration in aging and Alzheimer's disease. However, the association of neighborhood deprivation with disease progression in behavioral-variant frontotemporal degeneration (bvFTD) is unknown.

Methods

We examined associations between tertiles of neighborhood deprivation, using the Area Deprivation Index (ADI), and survival in 311 individuals clinically diagnosed with bvFTD from the Penn FTD Center. In a subset (n = 161) with complete baseline data across measures of global cognition, executive function, and language, we examined the association of ADI with longitudinal change.

Results

Compared to adults living in the least deprived neighborhoods, those li

SUBMITTER: Boyle R 

PROVIDER: S-EPMC12674657 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature