A Case of Chemoradiotherapy with Interstitial Brachytherapy for the Definitive Treatment of Early-Stage Vaginal Carcinosarcoma in a Young Adult Patient: Achieving Disease Control while Maintaining Sexual Function and Quality of Life.

ABSTRACT:

Introduction

Primary vaginal carcinosarcoma is extremely rare, with only 12 cases reported to date. A consensus has not been reached on the best treatment approach as most patients undergo surgery; however, the disease is highly refractory.

Case presentation

We present the case of a 34-year-old woman diagnosed with vaginal carcinosarcoma after experiencing vaginal pain and bleeding. She opted for organ preservation and underwent definitive chemoradiotherapy (dCRT) using interstitial brachytherapy, receiving an initial concurrent chemoradiotherapy dose of 50 Gy in 25 fractions with weekly cisplatin. This treatment was followed by brachytherapy, in which 22.5 Gy was delivered in three fractions. To prevent vaginal stenosis, the patient was advised to undergo regular vaginal ir

SUBMITTER: Kokubo Y 

PROVIDER: S-EPMC12674662 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature