Global Transmission and Evolution of Chikungunya Virus: Origins, Adaptive Mutations, and Intercontinental Spread of the Three Genotypes.

ABSTRACT: Chikungunya virus (CHIKV) is an arthropod-borne virus that has caused several major outbreaks around the world and is becoming increasingly harmful. Although significant progress has been made in understanding the global epidemiology and transmission of CHIKV, a systematic description of the transmission history of its three genotypes is still lacking. To address this gap, this study integrates multiple bioinformatics approaches to explore their origin, evolution, and transmission dynamics. We analyzed publicly available CHIKV genomes from NCBI to elucidate the genetic evolution and transmission potential of these genotypes. Phylogeographic and molecular evolutionary analyses showed that the West African (WA) genotype originated in Nigeria and spread exclusively within Africa; the Eastern/

SUBMITTER: Hao Y 

PROVIDER: S-EPMC12674863 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature