Serotype Diversity and Molecular Characterization of Foot-and-Mouth Disease Viruses From Outbreaks in Ethiopia (2019-2023): Re-Emergence of SAT 2 After 30 Years.

ABSTRACT: Ethiopia faces significant economic losses from foot-and-mouth disease (FMD). Laboratory diagnostic tools such as antigen detection ELISA (Ag-ELISA), reverse transcription polymerase chain reaction (RT-PCR), and sequencing provide important information that underpin control initiatives. In this study, 411 samples (275 epithelial tissues, 12 oropharyngeal probang cup scrapings and fluids, 122 swab samples, and two whole blood) collected from cattle with clinical signs of FMD were tested to determine serotype diversity of the FMD viruses (FMDVs) present in Ethiopia during a 5-year period (2019-2023). RT-PCR testing showed that most samples, 81.1% (172/212) were positive for FMDV genome while 48.2% (198/411) of the samples were positive for FMDV antigen using ELISA, identifying serotypes O (1

SUBMITTER: Gizaw D 

PROVIDER: S-EPMC12674864 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature