Global Prevalence of Microvascular Complications in Children and Adolescents With Type 1 and Type 2 Diabetes: A Systematic Review and Meta-Analysis.

ABSTRACT:

Aim

To quantify the prevalence of microvascular complications of children and adolescents with type 1 and type 2 diabetes by performing a meta-analysis of observational studies.

Methods

A systematic search in PubMed, EMBASE, and Web of Science was performed from 2000 to August 2025. Studies that reported the prevalence of microvascular complications in children and adolescents with diabetes were included. Study characteristics and prevalence estimates were extracted from each study. Pooled prevalence rates for microvascular complications were calculated using a random-effects model with Freeman-Tukey double arcsine transformation to stabilize variance.

Results

A total of 57 studies were included, comprising 51,819 children and adolescents diagnosed with diabetes (type

SUBMITTER: Ezzatvar Y 

PROVIDER: S-EPMC12674870 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature