Shared and Unique Structural Covariance Connectivity in Comorbidity of Obsessive-Compulsive Disorder and Major Depressive Disorder.

ABSTRACT:

Background

The comorbidity of obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) is a prevalent clinical phenomenon, which is associated with greater symptom severity, suicide risk, and poorer treatment outcomes. However, the neural basis of this comorbidity remains unclear. The aim of this study was to investigate the common and unique neural basis of comorbidity compared with OCD and MDD alone.

Methods

A total of 67 patients with comorbid OCD and MDD, 89 patients with OCD alone, 94 patients with MDD alone, and 94 healthy controls (HCs) completed the acquisition of T1-weighted structural images and were included in the present study. The gray matter volume of each brain region in the AAL116 atlas was calculated, based on which the structural covariance

SUBMITTER: Du H 

PROVIDER: S-EPMC12674874 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature