RTMS-induced motor cortex activation drives neural network tissueoid mediated spinal motor neural pathway reconstruction.

ABSTRACT: Rationale: The integration of biological and physical interventions represents a promising therapeutic strategy for spinal cord injury (SCI), offering a novel approach to restore disrupted motor pathways. This study investigates whether repetitive transcranial magnetic stimulation (rTMS) can prevent cerebral neuroapoptosis and promote the regeneration and integration of brain-derived nerve fibers with neural network tissueoids (NNToids) following SCI. Methods: Neural stem cell-derived NNToids were transplanted into rats with complete SCI and simultaneously treated with 10 Hz rTMS. Neuroinflammatory responses, neuroapoptosis, neuronal activation, and axonal regeneration were systematically evaluated using transcriptomic sequencing, histological validation, Western blotting, an

SUBMITTER: Xu J 

PROVIDER: S-EPMC12674999 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature