Longitudinal <i>in vivo</i> (<i>R</i>)-[¹⁸F]FBFP PET imaging for preclinical evaluation of cerebral sigma-1 receptor after ischemic stroke.

ABSTRACT: Rationale: Sigma-1 receptor (sigma-1R) is a promising biomarker and therapeutic target for ischemic stroke. However, the real-time changes in the expression of sigma-1R post-stroke have not been elucidated. (R)-1-(4-[¹⁸F]Fluorobenzyl)-4-[(tetrahydrofuran-2-yl)methyl]piperazine ((R)-[¹⁸F]FBFP) has emerged as a novel radiotracer targeting sigma-1R. This study aimed to use (R)-[¹⁸F]FBFP PET imaging for the investigation of spatiotemporal alterations in sigma-1R expression in the rat brain following stroke and treatment, and to explore the correlation between the imaging findings and neurological outcomes. Methods: Sigma-1R levels were evaluated on days 1, 3, 7, 14, 21, and 28 after middle cerebral artery occlusion (MCAO) usin

SUBMITTER: Yang J 

PROVIDER: S-EPMC12675007 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature