Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.

ABSTRACT:

Background

Depression is a risk factor for cardiometabolic diseases, but the extent to which this is attributable to genetic (rather than environmental) factors is unclear. Mendelian randomisation (MR) uses genetic variants to infer causality. We aimed to investigate the bidirectional association between respective genetic susceptibility to depression and cardiometabolic diseases.

Methods

We conducted a systematic review and meta-analysis of MR studies (unidirectional or bidirectional) in adults that assessed associations between genetic variants related to depression and any cardiometabolic disease. A comprehensive literature search of MEDLINE, EMBASE, PsycINFO, CINAHL, Scopus, Web of Science, and Cochrane Library was performed to capture relevant articles published between

SUBMITTER: Jabeen T 

PROVIDER: S-EPMC12675023 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature