Shorter or biomarker-guided antibiotic durations for common serious neonatal infections: a collection of non-inferiority meta-analyses.

ABSTRACT:

Background

Unnecessary antibiotic prolongation promotes antimicrobial resistance. Evidence-based guidance on antibiotic durations for treating neonatal infections is lacking. Noninferiority meta-analyses evaluating shorter durations or biomarker-guided durations have not been conducted.

Methods

We conducted systematic reviews and meta-analyses using a unified search strategy (MEDLINE, EMBASE, Cochrane Library, January 1990-December 2024) to determine whether short-course antibiotics are noninferior to "standard" courses for culture-positive sepsis, culture-negative sepsis, UTIs, uncomplicated/complicated meningitis, and fungal sepsis. Likewise, we determined whether biomarker-guided antibiotic durations are noninferior to "standard" courses for any sepsis. We included random

SUBMITTER: Dutta S 

PROVIDER: S-EPMC12675045 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature