<i>Lachnospira eligens</i> attenuates epileptogenesis via gut-brain axis regulation of blood-brain barrier integrity and neuroinflammation.

ABSTRACT: Rationale: Emerging evidence implicates the gut microbiota in epilepsy pathogenesis through the microbiota-gut-brain axis, yet the functional contribution of specific microbial taxa to epileptogenesis remains unclear. This study aimed to investigate whether Lachnospira eligens (L. eligens) can alleviate epileptic activity by modulating the gut-brain axis, with a focus on intestinal barrier integrity, blood-brain barrier (BBB) integrity, and neuroimmune responses. Methods: Using a cobalt wire-induced rat epilepsy model, we performed fecal 16S rDNA sequencing to assess gut microbiota alterations. Rats received daily oral gavage of L. eligens or PBS for 15 days, with colonization confirmed by qPCR. Seizure activity was monitored using long-term video electro

SUBMITTER: Li H 

PROVIDER: S-EPMC12675144 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature