Genistein supplementation modulates the intestinal microbiota-liver-lumbar muscle metabolic axis in DLY commercial pigs without concomitant changes in growth performance.

ABSTRACT: Genistein is widely found in leguminous plants. As an isoflavone, it has functions similar to mammalian estrogen and has effects on many aspects such as animal carcass performance, intestinal flora composition and physiological metabolism. This study aimed to investigate the effects of genistein supplementation on the carcass performance of commercial pigs via intestinal microorganisms, liver and lumbar muscle metabolites. Sixteen DLY commercial pigs were divided into two groups: a fed group receiving a diet supplemented with 160 mg/kg genistein and a control group without supplementation; the intervention lasted about 74 days. The bacterial genome of the 16SrRNA V3-V4 region was sequenced to observe the diversity and composition changes of microorganisms in the feces of the fed group and

SUBMITTER: Du Y 

PROVIDER: S-EPMC12675160 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature